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中国石油大学(华东)化学工程学院导师介绍:吕建仁


  姓 名: 吕建仁
  性 别: 男
  出生年月: 1962年10月
  职 称: 教授/博士生导师
  电 话: 0532-86981318
  民 族: 汉族
  单 位: 生物工程与技术中心
  文化程度: 博士
  电子邮箱: lujr@upc.edu.cn / j.lu@manchester.ac.uk
  
  研究领域
  (1)分子及细胞生物物理学
  (2)生物界面与表面相容性
  (3)脂质、肽、蛋白质、聚合物及其混合物的自组装与界面吸附
  (4)新型生物表面活性剂和功能肽的设计与合成、表面改性与制备
  (5)生物材料与组织工程
  (6)基因和药物的控制释放
  (7)生物工程与生物技术开发
  
  学术兼职
  (1)客座教授——
  西北大学客座教授
  大连理工大学客座教授
  四川大学客座教授
  (2)机构事务委员会成员——
  2002-2006:德国柏林中子散射中心(BENSC)提案评审委员
  2003-2007:法国格勒诺布尔劳厄-郎之万研究所(ILL)提案评审委员
  2006-2009:英国牛津卢瑟福-阿普尔顿实验室提案评审委员
  2002-2006:英国达斯伯里实验室第四代光源(4GLS)战略委员会成员
  2000-至今:英国EPSRC基金评审大学组成员
  2004-至今:英国物理研究所FInstP会员评估委员会成员
  2008-至今:国际医学与生物学工程联合会(IFMBE)下设的细胞与干细胞工程工作组成员
  
  教育经历
  1979-1983 中国石油大学 化学工程 学士
  1987-1990 英国赫尔大学 胶体与界面化学 博士
  1990-1995 牛津大学 物理化学 博士后
  
  科研成果
  1.英国“生物材料薄膜”专利(申请号0908372.6)发明者,于2009年5月15日由曼彻斯特大学授予
  2.英国“温度响应聚合物及其使用“专利(PCT/GB2010/050789)发明者,于2010年由曼彻斯特大学授予
  
  主要论著
  1. Han, S.; Xu, W.; Cao, M.; Wang, J.; Xia, D.; Xu, H.*; Zhao, X.; Lu, J. R.* Interfacial adsorption of cationic peptide amphiphiles: a combined study of in situ spectroscopic ellipsometry and liquid AFM. Soft Matter, DOI:10.1039/C1SM06203D. (SCI影响因子4.457)
  2. Chen, C.; Hu, J.; Zhang, S.; Zhou, P.; Zhao, X.; Xu, H.*; Zhao, X.; Yaseen, M.; Lu, J. R.* Molecular mechanism of antibacterial and Antitumor Actions of Designer Surfactant-like Peptides. Biomaterials, 2011, 33, 592-603 (SCI影响因子7.882)
  3. Hu, J.; Chen, C.; Zhang, S.; Zhao, X.; Xu, H.*; Zhao, X.; Lu, J. R.* Designed Antimicrobial and Antitumor Peptides with High Selectivity. Biomacromolecules, 2011, 12(11), 3839-3843 (SCI影响因子5.325)
  4. Rao, L.; Xue, Y.; Zhou, C.; Tao, J.; Li, G.; Lu, J. R.*; Ma, Y. A. thermostable esterase from Thermoanaerobacter Tengcongensis opening up a new family of bacterial lipolytic enzymes, Biochim. Biophys. Acta Proteins Proteomics 2011, 1814, 1695-1702.(SCI影响因子2.773)
  5. Cowsill, B.J.; Coffey, P.D.; Yaseen, M.; Waigh, T.A.; Freeman, N.J.; Lu, J. R.*. Measurement of the thickness of ultra-thin adsorbed globular protein layers with dual-polarisation interferometry: a comparison with neutron reflectivity. Soft Matter 2011, 7, 7223-7230.(SCI影响因子4.457)
  6. Liu, J.G.; Zhang, Z.Q.; Liu, Z.Q.; Zhu, H.; Dang, H.Y.; Lu, J. R.*; Cui, Z.F. Production of cold-adapted amylase by marine bacterium Wangia sp C52: optimization, modeling, and partial characterization. Marine Biotech. 2011, 13, 837 – 844. (SCI影响因子2.962)
  7. Liu, J.G.; Yin, M.M.; Wang, M.; Zhang, X.F.; Ge, B.S.; Liu, S.A.; Lu, J. R.*; Cui, Z.F. A novel membrane based process to isolate photosystem-I membrane complex from spinach. Photosyn. Research 2011, 107, 187-193. (SCI影响因子2.41)
  8. Cao, M.; Wang, Y.; Ge, X.; Cao, C.; Wang, J.; Xu, H.*; Xia, D.; Zhao, X.; Lu, J. R.* Effects of Anions on Nanostructuring of Cationic Amphiphilic Peptides. J. Phys. Chem. B, 2011, 115(41), 11862-11871 (SCI影响因子3.603)
  9. Han, S.; Cao, S.; Wang, Y.; Wang, J.; Xia, D.; Xu, H.*; Zhao, X.; Lu, J. R.* Self-assembly of Short Peptide Amphiphiles: The Cooperative Effect of Hydrophobic Interaction and Hydrogen Bonding. Chem. Eur. J. 2011, 17, 13095-13102(SCI影响因子5.476)
  10. Wu, C.; Wang, X.; Zhao, K.; Cao, M.; Xu, H.*; Xia, D.; Lu, J. R.* Molecular Modulation of Calcite Dissolution by Organic Acids. Crystal Growth Des. 2011, 11, 3153-3162. (SCI影响因子4.389)
  11. Wang, S.; Ge, X,; Xue, J.; Fan, H.; Mu, L.; Li, Y.; Xu, H.*; Lu, J.R.* Mechanistic Processes Underlying Biomimetic Synthesis of Silica Nanotubes from Self-Assembled Ultrashort Peptide Templates. Chem. Mater. 2011, 23, 2466. (SCI影响因子6.397)
  12. Tao, K.; Wang, J.; Zhou, P.; Wang, C.; Xu, H.*; Zhao, X.; Lu, J. R.* Self-assembly of Short Aβ (16-22) Peptides: The Effect of Terminal Capping and the Role of Electrostatic Interaction. Langmuir 2011, 27, 2723. (SCI影响因子4.268)
  13. Jia, D.; Tao, K.; Wang, J.; Wang, C.; Zhao, X.; Yaseen, M.; Xu, H.*; Que, G.; Webster, J. R. P.; Lu, J. R.* Interfacial Adsorption of Lipopeptide Surfactants at the Silica/water Interface Studied by Neutron Reflection. Soft Matter 2011, 7, 1777. (SCI影响因子4.457)
  14. Liu, J.G.; Yin, M.M.; Zhu, H.; Lu, J. R.*; Cui, Z.F. Purification and characterization of a hyperthermostable Mn-superoxide dismutase from Thermus thermophilus HB27. Extremophiles 2011, 15, 221-226. (SCI影响因子2.16)
  15. Zhao, Z.Q.; Chen, Z.B.; Zhao, X.B.; Pan, F.; Cai, M.H.; Wang, T.; Zhang, H.G.; Lu, J. R.*; Lei, M. Sphingosine-1-phosphate promotes the differentiation of human umbilical cord mesenchymal stem cells into cardiomyocytes under the designated culturing conditions. J. Biomed. Sci. 2011, 18, DOI: 10.1186/1423-0127-18-37. (SCI影响因子1.962)
  16. Zhao, X.B.; Pan, F.; Cowsill, B.; Lu, J. R.*; Garcia-Gancedo, L.; Flewitt, A.J.; Ashley, G.M.; Luo, J. Interfacial immobilization of monoclonal antibody and detection of human prostate-specific antigen. Langmuir 2011, 27, 7654-7662. (SCI影响因子4.268)
  17. Giamblanco, N.; Yaseen, M.; Zhavnerko, G., Lu, J. R.*; Marletta G. Fibronectin conformation switch induced by coadsorption with human serum albumin. Langmuir 2011, 27, 312-319. (SCI影响因子4.268)
  2010
  18. Xu, H.*; Wang, Y.; Ge, X.; Han, S.; Wang, S.; Zhou, P.; Shan, H.; Zhao, X.; Lu, J.R.* Twisted Naotubes Formed from Ultrashort Amphiphilic Peptide I3K and Their Templating for the Fabrication of Silica Nanotubes. Chem. Mater. 2010, 22, 5165. (SCI影响因子6.397)
  19. Zhao, X.; Pan, F.; Xu, H.; Yaseen, M.; Shan, H.; Hauser, C.A.E.*; Zhang, S.*; Lu, J.R.* Molecular Self-assembly and Applications of Designer Peptide Amphiphiles. Chem. Soc. Rev. 2010, 39, 3480. (SCI影响因子26.583)
  20. Wang, X.; Wu, C.; Tao, K.; Zhao, K.; Wang, J.; Xu, H.*; Xia, D.; Shan, H.; Lu, J. R.* Influence of Ovalbumin on CaCO3 Precipitation during in vitro Biomineralization. J. Phys. Chem. B 2010, 114, 5301. (SCI影响因子3.603)
  21. Chen, C.; Pan, F.; Zhang, S.; Hu, J.; Cao, M.; Wang, J.; Xu, H.*; Zhao, X.; Lu, J. R.* Antibacterial Activities of Short Designer Peptides: A Link between Propensity for Nanostructuring and Capacity for Membrane Destabilization. Biomacromolecules 2010, 11, 402. (SCI影响因子5.325)
  22. Yang, L.; Pan, P.; Zhao, X.B.; Yaseen, M.; Padia, F.; Coffey, P.; Freund, A.; Yang, L.; Liu, L.; Ma, X.; Lu, J. R.* Thermo-responsive copolymer nanofilms for controlling cell adhesion, growth and detachment. Langmuir 2010, 26, 17304-17314. (SCI影响因子4.268)
  23. Yaseen, M.; Zhao, X.B.; Freund, A.; Seifalian, A.M.; Lu, J. R.* Surface structural conformations of fibrinogen polypeptides for improved biocompatibility. Biomaterials 2010, 31, 3781-3792. (SCI影响因子7.882)
  24. Pan, F.; Zhao, X.B.; Perumal, S.; Waigh, T.A.; Lu, J. R.*; Webster, J.R.P. Interfacial dynamic adsorption and structure of molecular layers of peptide surfactants. Langmuir 2010, 26, 5690-5696. (SCI影响因子4.268)
  2009年
  25. Wang, J.; Han, S.; Meng, G.; Xu, H.*; Xia, D.; Zhao, X.; Schweins, R.;Lu, J. R.* Dynamic Self-assembly of Surfactant-like Peptides A6K and A9K. Soft Matter 2009, 5, 3870. (SCI影响因子4.869)
  26. Wang, X.; Kong, R.; Pan, X.; Xu, H.*; Xia, D.; Shan, H.; Lu, J. R.* Role of Ovalbumin in the Stabilization of Metastable Vaterite in Calcium Carbonate Biomineralization. J. Phys. Chem. B 2009, 113, 8975. (SCI影响因子3.471)
  27. Xu, H.*; Wang, J.; Han, S.; Wang, J.; Yu, D.; Zhang, H. Xia, D.; Zhao, X.; Waigh, T.A.; Lu, J. R.* Hydrophobic Region Induced Transitions in Self-assembled Peptide Nanostructures. Langmuir 2009, 25, 4115. (SCI影响因子3.8981)
  28. Wang, X.; Sun, H.; Xia, Y.; Chen, C.; Xu, H.*; Shan, H.; Lu, J. R.* Lysozyme Mediated Calcium Carbonate Mineralization. J. Colloid and Interface Sci. 2009, 332, 96. (SCI影响因子3.019)
  29. Rao, L.; Zhao, X.; Pan, F.; Li, Y.; Xue, Y.; Ma, Y.; Lu, J. R.* Solution behaviour and activity of a halophilic esterase under high salt concentration. PLoS One 2009, 4, e6980. (SCI影响因子4.411)
  30. Xiao, Z.; Ma, C.; Xu, P.; Lu, J. R.* Acetoin catabolism and acetylbutanediol formation by Bacillus pumilus in a chemically defined medium. PLoS One 2009, 4, e5627. (SCI影响因子4.411)
  31. Zhao, X.; Pan, F.; Holt, C.M.; Lewis, A.L.; Lu, J. R.* Controlled delivery of antisense oligonucleotides: a brief review of current strategies. Expert Opinion on Drug Delivery 2009, 6, 673-686. (SCI影响因子4.482)
  32. Zhao, X.; Pan, F.; Lu, J. R.* Interfacial assembly of proteins and peptides: recent examples studied by neutron reflection. J. Roy. Soc. Interface 2009, 6, S659–S670. (SCI影响因子4.259)
  33. Coffey, P.D.; Swann, M.J.; Waigh, T.A.; Schedin, F.; Lu, J. R.* Multiple path length dual polarization interferometry. Optics Express 2009, 17, 10959-69. (SCI影响因子3.749)
  34. Zhao, X.B.; Pan, F.; Perumal, S.; Xu, H.; Lu, J. R.*; Webster, J.R.P. Interfacial assembly of cationic peptide surfactants. Soft Mater 2009, 5, 1630-1638. (SCI影响因子4.457)
  35. Wang, S.J.; Fan, X.D.; Kong, J.; Lu, J. R.* Synthesis, characterization and UV curing kinetics of hyperbranched polysiloxysilanes from A(2) and CB2 type monomers. Polymer 2009, 50, 3587-3594. (SCI影响因子3.828)
  2008年
  36. Wang, X.; Wang, Y.; Xu, H.*; Shan, H.; Lu, J. R.* Dynamic Adsorption of Monoclonal Antibody Layers on Hydrophilic Silica Surface: A Combined Study by Spectroscopic Ellipsometry and AFM. J. Colloid and Interface Sci. 2008, 323, 18. (SCI影响因子2.443)
  37. Xu, H.; Perumal, S.; Zhao, X.; Du, N.; Liu, X.Y.; Jia, Z.; Lu, J. R.* Interfacial Adsorption of Antifreeze Proteins: A Neutron Reflection Study. Biophys. J. 2008, 94, 4405. (SCI影响因子4.683)
  38. Pan, F.; Zhao, X.B.; Waigh, T.A.,; Lu, J. R.*; Miano, F. Interfacial adsorption and denaturization of human milk and recombinant rice lactoferrin. Biointerphases 2008, 3, issue 2, pages FB36-FB43. (SCI影响因子3.118)
  39. Zhao, X.B.; Pan, F.; Coffey, P.; Lu, J. R.* Cationic copolymer-mediated DNA immobilization: interfacial structure and composition as determined by ellipsometry, dual polarization interferometry, and neutron reflection. Langmuir 2008, 24, 13556-13564. (SCI影响因子4.268)
  40. Jahnel, M.; Waigh, T.A.; Lu, J. R.* Thermal fluctuations of fibrin fibres at short time scales. Soft Matter 2008, 4, 1438-1442. (SCI影响因子4.457)
  41. Rogers, S.S.; Waigh, T.A.; Lu, J. R.* Intracellular microrheology of motile Amoeba proteus. Biophys. J. 2008, 94, 3313-3322. (SCI影响因子4.218)
  42. Zhang, Z.; Cao, X.; Zhao, X.; Holt, C.M.; Lewis, A.L.; Lu, J. R.*. J. Controlled delivery of anti-sense oligodeoxynucleotide from multilayered biocompatible PC polymer films. Controlled Release 2008, 130, 69-76. (SCI影响因子7.164)
  43. Yaseen, M.; Salacinski, H.J.; Seifalian, A.M.; Lu, J. R.* Dynamic protein adsorption at the polyurethane copolymer/water interface. Biomed. Mater. 2008, 3, article number 034123 (12pp). (SCI影响因子2.467)
  44. Zhao, X.B.; Zhang, Z..Q; Pan, F., Waigh, T.A., Lu, J. R.* Plasmid DNA complexation with phosphorylcholine diblock copolymers and its effect on cell transfection. Langmuir 2008, 24, 6881-6888. (SCI影响因子4.268)
  2007年
  45. Xu, H.; Zhao, X.; Lu, J. R.* Williams, D.E. Relationship between the Structural Conformation of Monoclonal Antibody Layers and Antigen Binding Capacity. Biomacromolecules 2007, 8, 2422. (SCI影响因子4.168)
  46. Miano, F.; Zhao, X.; Lu, J. R.*; Penfold, J. Coadsorption of human milk lactoferrin into the DPPC phospholipid monolayer spread at the air/water Interface. Biophys. J. 2007, 92, 1254-1262. (SCI影响因子4.218)
  47. Lu, J. R.*; Zhao, X.; Yaseen, M. Protein adsorption studied by neutron reflection. Curr. Opin. Colloid Interface Sci. 2007, 12, 9-16. (SCI影响因子6.13)
  48. Lu, J. R.*; Zhao, X.; Yaseen, M. Biomemitic surfactants: biosurfactants. Curr. Opin. Colloid Interface Sci. 2007, 12, 60-67. (SCI影响因子6.13)
  49. Zhao, X; Zhang, Z.; Pan, P.; Grant, C.; Ma, Y.H.; Armes, S.P.; Lewis, A.L.; Lu, J. R.* Structure of antisense oligonucleotide complexes obtained using a cationic diblock copolymer vector: correlation with cellular transfection efficiency. Biomacromolecules 2007, 8, 3493 -3502. (SCI影响因子5.325)

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