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浙江大学医学院导师介绍:毛亚飞

  
  姓名:毛亚飞
  性别:女
  所在学院:医学院
  职称:副教授

  研究方向:
  重要病原微生物基因工程疫苗及微生物相关药物的研制

  一、主要经历
  2004-至今 浙江大学医学院  副教授,硕导
  1998-2004 浙江大学医学院  讲师
  1993-1998 浙江医科大学   助教
  二、研究领域
  ●病原菌基因工程疫苗及相关药物研制
  主要研究幽门螺杆菌基因工程疫苗、金葡菌肠毒素相关药物研制。
  三、科研项目
  主持省部级科研项目1项,作为主要成员参与国家自然科学基金项目或省部科研项目多项。

  四、研究论文
  2000年以来,在浙江大学规定的国家一级学术期刊上发表论文20余篇、SCI收录杂志上发表论文12篇。近年发表的主要SCI论文如下:
  1.Jie Yan, Li-Li Chen, Yi-Hui Luo, Ya-Fei Mao, Meng He.High frequency of HGV and TTV infections in blood donors in Hangzhou, WJG, 2001, 7(5): 637-641(SCI)4/5
  2.Ya-Fei Mao, Jie Yan, Li-Wei Li, Li shu-ping.Construction of hpaA gene from a clinical isolate of Helicobacter pylori and identification of the fusion protein.WJG, 2003, 9(7):1529-1535(SCI)1/4
  3.Jie Yan, Shao-Hui Liang, Ya-Fei Mao, Li-Wei Li, Shu-Ping Li.Construction of expression systems for flaA and flaB genes of Helicobacter pylori and determination of immunoreactivity and antigenicity of the recombinant proteins.WJG, 2003,9(10):2240-2250(SCI)3/5
  4.Ya-Fei Mao, Jie Yan.Construction of prokaryotic expression system of ureB gene from a clinical Helicobacter pylori strain and identification of the recombinant protein immunity WJG, 2004, 10(7):977-984
  5.Jie Yan, Ya-Fei Mao.Construction of prokaryotic expression system of vacA gene and detection of vacA gene, VacA protein and antibody in Helicobacter pylori isolates and patients’ sera WJG, 2004, 10 (7):985-990
  6.Jie Yan, Ya-Fei Mao, Zhe-Xin Shao.Frequencies of the expression of main protein antigens from Helicobacter pylori isolates and production of specific serum antibodies in the infected patients.WJG,2005, 11(3):421-425
  7.Ping Ruan, Xiao-Ping Xia, Dexter Sun, David M.Ojcius, Ya-Fei Mao, Wen-Yan Yue, Jie Yan (corresponding author).Recombinant SpaO and H1a as immunogens for protection of mice from lethal infection with Salmonella paratyphi A: Implications for rational design of typhoid fever vaccines.Vaccine, 2008, 26: 6639-6644
  8.Luo DJ, Xue F, Ojcius DM, Zhao JF, Mao YF, Li LW, Lin XA, Yan J (corresponding author).Protein typing of major outer membrane lipoproteins from Chinese pathogenic Leptospira spp.and characterization of their immunogenicity.Vaccine, 2009, 28: 243-255.
  9.Ai Hua Sun, Ya Fei Mao, Ye Hu, Qi Sun, Jie Yan (corresponding author).Sensitive and specific ELISA coated by TpN15-TpN17-TpN47 fusion protein for detection of antibodies to Treponema pallidum.Clin Chem Lab Med (CCLM), 2009, 47:321-326.
  10.Dandan Jin, David M.Ojcius, Dexter Sun, Haiyan Dong, Yihui Luo, Yafei Mao, Jie Yan (corresponding author).Leptospira interrogans Induces Apoptosis in Macrophages via Caspase-8- and Caspase-3-Dependent Pathways.Infect Immun, 2009, 77: 799-809.
  11.Haiyan Dong, Ye Hu, Feng Xue, Dexter Sun, David M.Ojcius, Yafei Mao, Jie Yan (corresponding author).Characterization of the ompL1 gene of pathogenic Leptospira species in China and cross-immunogenicity of the OmpL1 protein.BMC Microbiol, 2008, 8: 223-235.
  12.Liu Y, Zheng W, Li L, Mao Y, Yan J (corresponding author).Pathogenesis of leptospirosis: interaction of Leptospira interrogans with in vitro cultured mammalian cells.J Med Microbiol Immunol, 2007, 196: 233-239
  13.Lei Zhang, Chenglin Zhang, David M.Ojcius, Jinfang Zhao, Xu’ai Lin, Yafei Mao, Liwei Li, Jie Yan (corresponding author).Identification of Mce as a critical outer membrane protein of pathogenic Leptospira species responsible for RGD motif-dependent adherence and host-cell invasion.Mol Microbiol, 2010, In revision.(manuscritp No.: MMI-2010-09754)
  14.毛亚飞,张悟澄,潘劲草.磁珠-ELISA检测日本血吸虫循环虫卵抗原的研究.中国寄生虫学与寄生虫病杂志,2002,20(6):372-373
  15.毛亚飞,严杰,李立伟.幽门螺杆菌hpaA基因的克隆和表达及鉴定.浙江大学学报(医学版),2003, 32(1):9-12
  16.梁韶辉,毛亚飞,严杰.幽门螺杆菌临床菌株flaB基因的克隆和表达及鉴定.浙江大学学报(医学版),2003, 32(1):13-16
  17.毛亚飞,严杰,徐飏.幽门螺杆菌内置佐剂UreB和HpaA双价重组疫苗对实验感染小鼠的免疫保护作用.浙江大学学报(医学版),2005, 34(5):405-411
  18.徐水凌,毛亚飞,张梅光,罗冬娇,严杰.葡萄球菌肠毒素A基因原核表达系统的构建及其表达产物促淋巴细胞增殖和抑制肿瘤细胞生长作用的研究.中国病理生理杂志2007,23(1):163-167
  19.毛亚飞,徐水凌,罗冬娇,严杰.葡萄球菌肠毒素B基因原核表达系统的构建及其表达产物促淋巴细胞增殖和抑制肿瘤细胞生长作用的研究.浙大学报理学版,2006,33(5):553-558
  20.毛亚飞,林晓骥,李晶,阮萍,周晓辉,严杰.甲型副伤害杆菌侵袭蛋白spaO原核表达及免疫性和保护性研究。中华流行病学杂志,2006,27(4):347-350
  21.范芳华,严杰,毛亚飞。SEA基因定位突变体构建及其重组表达产物生物学活性的研究
  22.中华微生物学与免疫学杂志, (通讯作者)
  23.王学海 毛亚飞 严杰 幽门螺杆菌UREB抗原表位预测及其有效表位噬菌体展示的筛选。中华微生物学与免疫学杂志,2007,27(5):432-437

  五、参编的主要教材、专著与发明专利
  1.毛亚飞(参编) 普通高等教育“十一五”国家级规划教材《医学微生物学》,第一版,高等教育出版社,2008.6
  2.毛亚飞(副主编) 钩端螺旋体病学,第三版,北京:人民卫生出版社,2006.
  3.毛亚飞(参编) 临床分子细菌学,第一版,北京:人民卫生出版社,2005.
  4 毛亚飞(参编)《机会性寄生虫病》,第一版,北京:人民卫生出版社,2009.5
  六、科研成果奖及荣誉
  获得浙江省科技成果二等奖2项(2007、2003)、三等奖1项(2007),浙江省教育厅科技进步二等奖1项(2006)。发明专利1项。

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